abstract：:While there has been an overall decline of tobacco and alcohol-related head and neck cancer in recent decades, there has been an increased incidence of HPV-associated oropharyngeal cancer (OPC). Recent research studies and clinical trials have revealed that the cancer biology and clinical progression of HPV-positive O...

authors： Salzillo TC,Taku N,Wahid KA,McDonald BA,Wang J,van Dijk LV,Rigert JM,Mohamed ASR,Wang J,Lai SY,Fuller CD

更新日期：2021-10-01 00:00:00

abstract：:Photosensitization of natural organic matter (NOM) is an important natural source of reactive bromine species (RBrS) in the environment. Up to now, quantitative information about RBrS was mainly based on model sensitizers. Whether the behavior of model compounds could represent those of complex NOM remains unknown. In...

authors： Wang K,Zhu X,Chen B

更新日期：2021-10-01 00:00:00

abstract：:The oral microbiome is a community of microorganisms, comprised of bacteria, fungi, viruses, archaea, and protozoa, that form a complex ecosystem within the oral cavity. Although minor perturbations in the environment are frequent and compensable, major shifts in the oral microbiome can promote an unbalanced state, kn...

authors： Radaic A,Ganther S,Kamarajan P,Grandis J,Yom SS,Kapila YL

更新日期：2021-10-01 00:00:00

abstract：:Triclosan (TCS), an emergent pollutant, is raising a global concern due to its toxic effects on organisms and aquatic ecosystems. The non-availability of proven treatment technologies for TCS remediation is the central issue stressing thorough research on understanding the underlying mechanisms of toxicity and assessi...

authors： Kumar S,Paul T,Shukla SP,Kumar K,Karmakar S,Bera KK,Bhushan Kumar C

更新日期：2021-10-01 00:00:00

abstract：:Human papillomavirus (HPV) is a ubiquitous DNA virus that infects squamous epithelia. Though HPV only encodes 8 genes, it is capable of causing cellular transformation and ultimately cancer in host cells. In this article we review the classification of HPV viruses, their genetic structure and life cycle, viral gene bi...

authors： Cosper PF,Bradley S,Luo L,Kimple RJ

更新日期：2021-10-01 00:00:00

abstract：:The aim of this work was to study the associations of adipose tissue trace element concentrations with type 2 diabetes (T2DM) incidence over a 16-year follow-up period in an adult cohort from Southern Spain. 16-year T2DM incidence was gathered from hospital records. Chemical analyses of Cr, V, Zn, Fe, Cu and Se in adi...

authors： Rodríguez-Pérez C,Gómez-Peña C,Pérez-Carrascosa FM,Vrhovnik P,Echeverría R,Salcedo-Bellido I,Mustieles V,Željka F,Arrebola JP

更新日期：2021-10-01 00:00:00

abstract：:In low-stakes assessments, some students may not reach the end of the test and leave some items unanswered due to various reasons (e.g., lack of test-taking motivation, poor time management, and test speededness). Not-reached items are often treated as incorrect or not-administered in the scoring process. However, whe...

authors： Gorgun G,Bulut O

更新日期：2021-10-01 00:00:00

abstract：:Cyclin-dependent kinase 4 (CDK4) is a critical molecule that regulates key aspects of cell proliferation through phosphorylation of the retinoblastoma (Rb) family of proteins. In the last few years, it has been suggested that CDK4 plays alternative roles in cell proliferation and tumorigenesis. The main aim of the pre...

authors： Lee SH,Rodriguez LRL,Majumdar R,De Marval PLM,Rodriguez-Puebla ML

更新日期：2021-10-01 00:00:00

abstract：:To the best of our knowledge, the oncogenic role of circular RNA solute carrier family 26 member 4 (circSLC26A4) has only been reported in cervical cancer, while its role in non-small cell lung cancer (NSCLC) is unknown. The present study explored the involvement of circSLC26A4 in NSCLC. NSCLC tissues and paired adjac...

authors： Chen Q,Li H,Liu J

更新日期：2021-10-01 00:00:00

abstract：:This study evaluated the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple oral doses of enpatoran (formerly named M5049), a new toll-like receptor (TLR) 7 and 8 dual antagonist, and the effect of food on a single dose in healthy participants. In this single phase 1, randomi...

authors： Port A,Shaw JV,Klopp-Schulze L,Bytyqi A,Vetter C,Hussey E,Mammasse N,Ona V,Bachmann A,Strugala D,Reh C,Goteti K

更新日期：2021-10-01 00:00:00

abstract：:Increased amounts of starch and sugar have been added to the diet in the Western world during the last decades. Undigested carbohydrates lead to bacterial fermentation and gas production with diffusion of water, causing abdominal bloating, pain and diarrhea. Therefore, dietary advice is the first line of treatment of ...

authors： Ohlsson B

更新日期：2021-10-01 00:00:00

abstract：:Interferon (IFN) α is used for the treatment of chronic hepatitis B virus (HBV) infection, but the molecular mechanisms underlying its antiviral effect have not been fully elucidated. Epigenetic modifications regulate the transcriptional activity of covalently closed circular DNA (cccDNA) in cells with chronic HBV inf...

authors： Moon IY,Kim JW

更新日期：2021-10-01 00:00:00

abstract：Objectives:To determine salivary melatonin and malondialdehyde levels in individuals with and without dental caries. Materials and methods:Saliva samples were collected in a fasting state from patients with active dental caries (n ​= ​16) and patients without dental caries (n ​= ​16). Melatonin was measured in the sam...

authors： Saeralaathan S,Rajkumar A,Balaji TM,Raj AT,Ganesh A

更新日期：2021-10-01 00:00:00

abstract：:Chronic alcohol abuse increases the risk of mortality and poor outcomes in patients with acute respiratory distress syndrome. However, the underlying mechanisms remain to be elucidated. The present study aimed to investigate the effects of chronic alcohol consumption on lung injury and clarify the signaling pathways i...

authors： Deng W,He J,Tang XM,Li CY,Tong J,Qi D,Wang DX

更新日期：2021-10-01 00:00:00

abstract：:There are several types of liver injury, including alcohol‑induced liver injury, drug‑induced liver injury, infectious liver injury, cirrhosis, liver ischemia/reperfusion injury and liver failure. In recent years, accumulated data have demonstrated that microRNAs (miRNAs/miRs) may be involved in the occurrence and dev...

authors： Feng X,Bao J,Song C,Xie L,Tan X,Li J,Jia H,Tian M,Qi J,Qin C,Bian H

更新日期：2021-10-01 00:00:00

abstract：:[This corrects the article DOI: 10.1016/j.jcot.2020.04.002.][This corrects the article DOI: 10.1016/j.jcot.2020.06.040.][This corrects the article DOI: 10.1016/j.jcot.2020.10.007.][This corrects the article DOI: 10.1016/j.jcot.2020.08.021.][This corrects the article DOI: 10.1016/j.jcot.2020.05.001.][This corrects the ...

authors：

更新日期：2021-10-01 00:00:00

abstract：:Oral cancer is the most common cancer among males in the Sri Lankan population. The aim of this study was to assess the health seeking behaviors and associated factors for OPMD. A hospital based descriptive cross-sectional study was conducted among Out Patients Department attendees of the Institute of Oral Health, Mah...

authors： Amarasinghe H,Rathnapriya M,Abeysundara A,Jayaweera S,Jayathilake A,Jayasinghe R

更新日期：2021-10-01 00:00:00

abstract：:Ischemic stroke is one of the most common causes of mortality worldwide and is a primary cause of disability and mortality in adults. There is an unmet need for drugs that can effectively treat ischemic stroke. Hence, the present study explored the neuroprotective effects of andrographolide (Andro) in a mouse model of...

authors： Li Y,Xiang LL,Miao JX,Miao MS,Wang C

更新日期：2021-10-01 00:00:00

abstract：:The aim of the present study was to explore the effect of chaperon‑mediated autophagy (CMA) through pyruvate kinase isoform M2 (PKM2) on the development of renal carcinoma (RCC) and its possible mechanisms. Lysosome‑associated membrane protein 2A (LAMP‑2A) and PKM2 expression levels were detected by collecting tissue ...

authors： Xiao S,Xu G,Wang Z,Chong T

更新日期：2021-10-01 00:00:00

abstract：:Ginsenoside Re (G‑Re) is a panaxatriol saponin and one of the pharmacologically active natural constituents of ginseng (Panax ginseng C.A. Meyer). G‑Re has antioxidant, anti‑inflammatory and antidiabetic effects. The present study aimed to investigate the effects of G‑Re on neuroinflammatory responses in lipopolysacch...

authors： Madhi I,Kim JH,Shin JE,Kim Y

更新日期：2021-10-01 00:00:00

abstract：:Applications of biochar to degraded soils have attracted considerable interest because of its capacity to enhance nutrients availability to the plants, sequester C and immobilize organic and inorganic pollutants. A five-year field experiment was conducted in a cotton-wheat system to investigate the effect of different...

authors： Singh G,Mavi MS,Choudhary OP,Gupta N,Singh Y

更新日期：2021-10-01 00:00:00

abstract：:A number of drugs and other triggers can cause acute liver injury (ALI) in clinical practice. Therefore, identifying a safe drug for the prevention of liver injury is important. The aim of the present study was to investigate the potential preventive effect and regulatory mechanism of urantide on carbon tetrachloride ...

authors： Li Y,Guo Z,Cui H,Wang T,Xu Y,Zhao J

更新日期：2021-10-01 00:00:00

abstract：:The role and mechanism of elagitannase is misunderstood because it exhibited different activities due to the low purity or complexity of substrates, and there is no available information about the biochemical, physicochemical and molecular characteristics of the enzyme. This study was aimed to obtain enzymatic extract...

authors： Buenrostro-Figueroa J,Gutierrez-Sánchez G,Prado-Barragán LA,Rodríguez-Herrera R,Aguilar-Zárate P,Sepúlveda L,Ascacio-Valdés JA,Tafolla-Arellano JC,Aguilar CN

更新日期：2021-10-01 00:00:00

abstract：:A novel process that combines partial nitrification, fermentation and Anammox-partial denitrification (NFAD) was proposed to co-treat ammonia rich sludge supernatant (NH4+-N = 1194.1 mg/L), external WAS (MLSS = 22092.6 mg/L) and WWTP secondary effluent (NO3--N = 58.6 mg/L). Three separated reactors were used for parti...

authors： Zhang F,Peng Y,Wang Z,Jiang H,Ren S,Qiu J

更新日期：2021-10-01 00:00:00

abstract：:Amidst a global pandemic, a precise and widely accessible rapid detection method is needed for accurate diagnosis and contact tracing. The lack of this technology was exposed through the outbreak of SARS-CoV-2 beginning in 2019. This study sets the foundation for the development of a boron doped diamond (BDD)-based im...

authors： Witt S,Rogien A,Werner D,Siegenthaler J,Lesiyon R,Kurien N,Rechenberg R,Baule N,Hardy A,Becker M

更新日期：2021-10-01 00:00:00

abstract：:Here, we revealed the effects of microbes on fulvic acid (FA) formation in composting by adding MnO2. The results showed that the MnO2 promoted the formation of highly humified components (79.2% increased for component 2, and 45.8% increased for component 3) in FA. Additionally, core bacteria involved in FA transforma...

authors： Qi H,Zhai W,Du Y,Zhao Y,Wei Z,Wu J,Xie X,Yang H,Wu D,Guo T

更新日期：2021-10-01 00:00:00

abstract：:Performance of enhanced biological phosphorus removal (EBPR) is often investigated with simple synthetic wastewater containing volatile fatty acids (VFAs). In this study, various (fermentable) substrates, individually and in mixtures, were examined during the application of a granulation strategy. In addition, the mic...

authors： Dockx L,Caluwé M,De Vleeschauwer F,Dobbeleers T,Dries J

更新日期：2021-10-01 00:00:00

abstract：:This is the first review presenting and discussing Burkholderia sacchari as a bacterial chassis. B. sacchari is a distinguished polyhydroxyalkanoates producer strain, with low biological risk, reaching high biopolymer yields from sucrose (0.29 g/g), and xylose (0.38 g/g). It has great potential for integration into a ...

authors： Oliveira-Filho ER,Gomez JGC,Taciro MK,Silva LF

更新日期：2021-10-01 00:00:00

abstract：:Cellulose is well known as a biocompatible material or natural reducing material. In this study, As an eco-friendly and facile method, we prepared monodispersed silver nanoparticles (AgNPs) in cellulose-framework through photocatalytic reaction. and we fabricated electrospun fiber scaffolds with excellent antibacteria...

authors： Ko SW,Lee JY,Rezk AI,Park CH,Kim CS

更新日期：2021-10-01 00:00:00

abstract：:Chitin is mainly extracted from crustaceans, but this resource is seasonally dependent and can represent a major drawback to satisfy the traceability criterion for high valuable applications. Insect resources are valuable alternatives due to their lower mineral content. However, the deacetylation of chitin into chitos...

authors： Huet G,Hadad C,González-Domínguez JM,Courty M,Jamali A,Cailleu D,van Nhien AN

更新日期：2021-10-01 00:00:00

abstract：:The presence of polyfunctional ligands on the bio-macromolecules acts as an efficient adsorbent for heavy metal ions. Starch is one of the most abundant, easily available and cheap biopolymer of plant origin. However, native starch exhibits significantly low adsorption capacity due to the absence of some essential fun...

authors： Gupta AD,Rawat KP,Bhadauria V,Singh H

更新日期：2021-10-01 00:00:00

abstract：:Hyaluronic acid (HA) is a naturally formed acidic mucopolysaccharide, with excellent moisturising properties and used widely in the medicine, cosmetics, and food industries. The industrial production of specific molecular weight HA has become imperative. Different biological activities and physiological functions of H...

authors： Qiu Y,Ma Y,Huang Y,Li S,Xu H,Su E

更新日期：2021-10-01 00:00:00

abstract：:Two C1/C4-oxidizing AA9 lytic polysaccharide monooxygenases (AA9 LPMOs), AoLPMO9A and AoLPMO9B, and one C4-oxidizing AoLPMO9C from Aspergillus oryzae, were characterized and compared with the well-studied C4-oxidizing NcLPMO9C. NcLPMO9C and AoLPMO9C harboring carbohydrate-binding module 1 (CBM1) exhibited much stronge...

authors： Chen K,Zhang X,Long L,Ding S

更新日期：2021-10-01 00:00:00

abstract：:This work investigated the effect of adding low concentrations of nano-SiO2 (0.5, 1.0 and 1.5%) in the properties of films based on sodium alginate, to identify lower thresholds in the proportion of the reinforcing agent. It was found that, even in the smallest proportion, thermal stability of the nanocomposites impro...

authors： Marangoni Júnior L,da Silva RG,Anjos CAR,Vieira RP,Alves RMV

更新日期：2021-10-01 00:00:00

abstract：:Sustainable bio-based adhesive is a promising substitute for petroleum-based adhesives to alleviate serious environmental and health problems. In this work, a nanoengineered starch-based adhesive was fabricated by grafting vinyl acetate (VAc) onto starch molecule and subsequently incorporating the functional nanoparti...

authors： Chen L,Din ZU,Yang D,Hu C,Cai J,Xiong H

更新日期：2021-10-01 00:00:00

abstract：:This work reports novel chitosan functionalized graphene oxide (GO) nanocomposites combined fluorescence imaging and therapeutic functions in one agent, which can serve as a promising alternative to alleviate related diseases caused hyperinflammation. Briefly, GO was designed to be conjugated with chitosan, fluorescei...

authors： Li Y,Yang Y,Shao Y,Sun Y,Si H,Miao J,Xu Y

更新日期：2021-10-01 00:00:00

abstract：Introduction:The COVID19 pandemic has turned out to be one of the public health* burdens in 2020. The fear of deaths due to COVID19 has surmounted even in developed countries and hasn't spared young age. This study aims in assessing the mortality due to COVID19 among patients below 30years of age in TamilNadu. Methods...

authors： Vijay Anand V,Arunkumar Yogaraj G,Priya S,Priya Raj P,Brinda Priyadharshini C,Sridevi PN

更新日期：2021-10-01 00:00:00

abstract：:The COVID-19 pandemic has contributed to decreases in breast, colorectal, and cervical cancer screenings between 86 and 94% compared to three-year averages. These postponed screenings have created backlogs that systems will need to address as healthcare facilities re-open for preventive care. The American Cancer Socie...

authors： Fisher-Borne M,Isher-Witt J,Comstock S,Perkins RB

更新日期：2021-10-01 00:00:00

abstract：:The COVID-19 pandemic affects mortality and morbidity, with disruptions expected to continue for some time, with access to timely cancer-related services a concern. For breast cancer, early detection and treatment is key to improved survival and longer-term quality of life. Health services generally have been strained...

authors： Breast Screening Working Group (WG2) of the Covid-19 and Cancer Global Modelling Consortium.,Figueroa JD,Gray E,Pashayan N,Deandrea S,Karch A,Vale DB,Elder K,Procopio P,van Ravesteyn NT,Mutabi M,Canfell K,Nickson C

更新日期：2021-10-01 00:00:00

abstract：:On-chip microparticle-based separation is a significant activity in analytical and biomedical field. Here, we reported an acoustic aggregation-induced microparticle separation for on-chip fluorescence detection of Alzheimer biomarkers. miRNA-101, an Alzheimer-related biomarker, was used as a model target to validate t...

authors： Sun Y,Luo Y,Xu T,Cheng G,Cai H,Zhang X

更新日期：2021-10-01 00:00:00